Witch hazel fractions were, in addition, more potent in arresting the cell cycle at the S phase and inducing apoptosis they also induced a significant percentage of necrosis. Witch hazel fractions were the most efficient in inhibiting cell proliferation in HT29 and HCT116 human colon cancer cell lines, which clearly shows that the more galloylated the fractions, the more effective they were at inhibiting proliferation of colon cancer cells. The results are compared with those obtained previously with homologous fractions from grape (less galloylated) and pine (nongalloylated). This study examines the response of human colon cancer cells to treatment with fractions obtained from a witch hazel polyphenolic extract. They are particularly rich in gallate esters included in proanthocyanidins, hydrolyzable tannins (galloylated sugars), and methyl gallate. Witch hazel ( Hamamelis virginia) extracts are used in traditional medicine. Lizárraga, Daneida Touriño, Sonia Reyes-Zurita, Fernando J de Kok, Theo M van Delft, Joost H Maas, Lou M Briedé, Jacco J Centelles, Josep J Torres, Josep L Cascante, Marta
Witch hazel ( Hamamelis virginiana) fractions and the importance of gallate moieties-electron transfer capacities in their antitumoral properties.
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